Celiac disease
Celiac disease is a common multi-factorial enteropathy characterized by small intestine malabsorption and mucosal lesions resulting from ingestion of gluten. Celiac disease presents a strong association with major histocompatibility complex (MHC), in particular with HLA-DQ2 and HLA-DQ8 heterodimer. Over 90% of celiac patients carry the HLA-DQ2 heterodimer which is encoded by DQA1*05 and DQB1*02 alleles either in cis or in trans. Most DQ2 negative patients carries the heterodimer DQ 8 encoded by DBQA1*0301 and DB1*0302 alleles. Only a few number of celiac patients presents neither DQ2 heterodimer nor DQ8 heterodimer; many of them present only the β-chain of the DQ2 heterodimer.
| Ref. | Product | Technology | Size | Regulatory | Additional Info |
|---|---|---|---|---|---|
| CE.02RQ | Celiac disease risk kit 2 -RQ | Real Time PCR kit | 50 |  | DQ2, DQ8, DR alleles |
| CE.03RQ | Celiac disease risk kit 3 -RQ | Real Time PCR kit | 25 | | DQB1*02 allele homozigosity |
| K.CRT-RQ | Celiac RT | Real Time PCR kit | 50 | | DQ2 & DQ8 alleles |