Clonality and Lymphomas - (pdf info)

Within the oncology field Experteam offers kits to evaluate the polyclonal or monoclonal origin of T or B cell lymphomas. The technique for B cell analysis is based on specific amplification of V-D-J regions within the immunoglobin heavy chain ‘genes. Similar to the technique used in B cell lymphoma analysis is the technique for T cell lymphoma analysis using amplification of the V-J regions of the gamma chain genes of the T cell receptor.

Code Name of kit Technical specs Amount of tests Info Additional Info
BL.01 B cell lymphoma kit Agarose Gel Electrophoresis Kit 40 CE/IVD
BL.01FL B cell lymphoma kit-FL Capillary Electrophoresis Kit 40 CE/IVD Appl. Bios. & Beckman Coult.
TL.01 T cell lymphoma kit Agarose Gel Electrophoresis Kit 40 CE/IVD
TL.01FL T cell lymphoma kit-FL Capillary Electrophoresis Kit 40 CE/IVD Appl. Bios. & Beckman Coult.

Microsatellite Instability Analysis - (pdf info)

Approximately 10 to 15 % of sporadic colon and gastric cancers show the microsatellite instability phenotype (MSI), characterized by widespread somatic alterations in the length of the nucleotide repeat squence. MSI is also found in the majority of tumors from the familial syndrome, hereditary non-polyposis colorectal cancers (HNPCC or Lynch Syndrome). It is a reliable diagnostic marker for the identification of HNPCC and a molecular predictive marker for the identification of colon cancer patients that are susceptible for chemotherapy.
The technique used for the analysis of MSI in HNPCC kit 1 - FL kit is based on in vitro amplification using a single multiplex PCR of 5 repeated sequences of DNA (microsatellites). Abnormal lengths of the amplicons and the resulting instability of microsatellites are easily detected on capillary electrophoretic analysis.

Code Name of kit Technical specs Amount of tests Info Additional Info
MS.01FL HNPCC Kit 1 - FL Capillary Electrophoresis Kit 40 CE/IVD Appl. Bios. & Beckman Coult.
Top